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KMID : 0358819850120030309
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Journal of Korean Society of Plastic and Reconstructive Surgeons
1985 Volume.12 No. 3 p.309 ~ p.315
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AN EXPERIMENTAL STUDY OF BIOLOGICAL DRESSING BY DRIED HUMAN AMNIOTIC MEMBRANE
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Kim Won-Tak
Rhee Ki-Rung
Kim Seung-Hong
Min Dae-Hong
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Abstract
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Although remarkable progress was made recently in various medical fields including cancer treatment, there was no substantial one to be mentioned in treating burn patients as yet.
It is well known, however, that biological dressing has many benefits on healing of burned skin and that it actually lowers the mortality rate of extensive burn patients.
As a material for biological dressing, human amniotic membrane has been used throughout the world with popularity. But its availability was limited in terms of storage and sterilization.
In order to meet these problems and to apply large amount of membrane more easily, author has got fresh amniotic membrane prepared it serially as follows; drying, packing and storing in room temperature for three months.
Fifteen rabbits had encounted artificial second degree burn on the back. Both dried and fresh amniotic membrane were applied on the burn wounds respectively.
The healing process of the burn wounds covered with dried membrane was assessed grossly and histologically in comparison with those covered with fresh amniotic membrane.
In gross findings, there was no difference in the rate of crust formation, re-epithelization and adherence of the membrane.
In histological findings, well-matured epithelization was confirmed by both dried and fresh membranes. Cell arrangement and configuration of dried and fresh amniotic membrane were same except only shortened height of epithelial cell and reduced thickness of basement membrane and compact layer.
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KEYWORD
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